10 ’Omics You Need To Know

Confused by the proliferation of ‘omics but don’t want to be left behind? Fret not, Asian Scientist Magazine has got you covered with our handy explainer on the hottest ‘omics around.

Single-cell ‘omics

Cells shutterstock_75090052

Material studied: Cells
Methods used: Microfluidics, single molecule mRNA fluorescence in situ hybridization

Cells are their own individuals. Neighboring cells of the same type have unique profiles, and cancer cells within a tumor develop their own unique mutations. Yet, ‘omics approaches usually analyze large populations of cells—grinding up a tissue or organ sample—such that the results reflect the average of a population of cells.

Single-cell ‘omics aims to understand the profiles of individual cells, and address questions such as how microenvironments influence cell physiology.

Single cells are first captured using microdissection and microfluidics devices, before their genetic material is extracted and amplified for analysis.

Shuzhen received a PhD degree from the Johns Hopkins Bloomberg School of Public Health, USA, where she studied the immune response of mosquito vectors to dengue virus.

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