autoimmune disease
Tadamitsu Kishimoto Receives 2017 King Faisal International Prize
Professor Tadamitsu Kishimoto has been awarded the King Faisal International Prize for Medicine for his role in developing therapies for autoimmune diseases.
Shimon Sakaguchi Wins 2017 Crafoord Prize
For his pioneering work in immune regulation, Professor Shimon Sakaguchi has been recognized with the 2017 Crafoord Prize in Polyarthritis.
Tracing The Dendritic Cell Family Tree
A single-cell RNA sequencing study has shown that dendritic cells are already committed to their downstream lineages in the bone marrow.
How Proteases Train T-Cells
Protein cutting enzymes only found in the thymus preferentially generate peptides that lead to the positive selection and subsequent differentiation of T-cells.
DNA-TLR9 Zipper Triggers Autoimmune Response
A zipper-like arrangement of DNA can bind strongly to the receptor TLR9 and trigger a strong immune response.
How Inflammation Switches Off Tregs
DBC1, which has recently been shown to decrease the stability of immune suppressing transcription factor FOXP3, could be a therapeutic target for autoimmune diseases.
When B Cells Go Rogue
Inactivation of the death receptor FAS allows rogue B cells to escape antigen control and drive autoimmunity.
Lilly & Hanmi Ink US$690 Million Deal
Eli Lilly has acquired Hanmi's BTK inhibitor HM71224, a small molecule soon to enter Phase II trials for autoimmune diseases.
How Peptide Binding Influences Autoimmunity
Smaller peptides that are not anchored to the MHC molecule could potentially cause autoimmunity by activating self-reactive T-cells.
Monash & Janssen To Develop New Autoimmune Meds
The academia-industry alliance between Monash and Janssen will investigate new treatments for autoimmune diseases.
