AsianScientist (May 14, 2015) – Chinese scientists have reared beef rich in the beneficial fatty acids associated with fish oils. The study, published in the journal Biotechnology Letters, also highlights the scientific challenges that remain.
The team from Northwest Agricultural and Forestry University and the National Beef Cattle Improvement Center, both in Yangling (Shaanxi), successfully introduced a gene into fetal cells from Luxi Yellow cattle, a Chinese breed with a high beef yield. The fat1 gene, isolated from a nematode worm, codes for desaturase enzymes that are involved in the conversion of n-6 to n-3 polyunsaturated fatty acids.
A diet rich in long chain n-3 polyunsaturated fatty acids, also known as omega-3 oils, can help protect against cardiovascular diseases, obesity and neurodegenerative diseases. However, levels of these fatty acids in the human diet have decreased over the years and the levels of shorter chain n-6 fatty acids have increased. Introducing the fat1 gene to cattle increased the levels of beneficial oils by over five times.
“We have provided the first evidence that it is possible to create a new breed of cattle with higher nutritional value in terms of their fatty acid composition,” says corresponding author Professor Zan Linsen from the College of Animal Science and Technology at the university.
Other research groups are experimenting with increasing levels of omega-3 oils in farmed fish by creating fishmeal rich in a new plant source. A similar strategy could be used for cattle-producing feedstock rich in omega-3s—but the new study shows that elevated levels can be directly produced in beef. Similar genes have previously been introduced to pigs, dairy cattle and sheep by international research groups.
Of the 14 calves that successfully received the fat1 gene, 11 died at less than four months old, mainly from inflammation and from haemorrhagic septicaemia, an infection common to cattle. Further research is needed to determine the causes. Abnormalities may result from the incomplete reprogramming of cells or from some genes being turned on and off during the generation of embryos.
“There is much to learn about the best scientific techniques and the best husbandry required to make beef a rich animal source of omega-3 oils for human nutrition, but we have taken the first step,” says lead author Dr. Cheng Gong.
The researchers believe that the results of their study could help ensure in the future that the beef that people eat is better for them.
The article can be found at: Cheng et al. (2015) Production Of Transgenic Beef Cattle Rich In n-3 PUFAs By Somatic Cell Nuclear Transfer.
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Source: Springer; Photo: Larry Hoffman/Flickr/CC.
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