Gut And Inner Ear Hair Cells Share Striking Similarities

The similarities in appearance and function of gut microvilli and stereocilia could help scientists to identify mutations of genes that may cause digestive diseases.

AsianScientist (Feb. 5, 2016) – Hong Kong researchers have found that gut microvilli and the stereocilia tip-link complexes are formed via strikingly similar interactions. Their findings were published in Developmental Cell.

Brush border microvilli are microscopic cellular membrane protrusions that increase the surface area of cells and carry out a wide variety of functions, including absorption, secretion and cellular adhesion.

Stereocilia, on the other hand, are mechanosensing organelles of hair cells, which respond to fluid motion in numerous types of animals for various functions, including hearing and balance. The two structures are located in separate parts of the human body and perform vastly different functions, despite the very similar looks and features they have.

The similarities between the two, in fact, are far more than just looks. Mechanistically, the two resemble one another as well.

“While brush border microvilli resemble the relatively well-characterized stereocilia of hair cells, the mechanistic basis of tip-link complex organization in brush border microvilli is poorly understood,” said Professor Zhang Mingjie from the Hong Kong University of Science and Technology.

In the study, the team of researchers performed systematic biochemical and structural characterizations of the protein interaction network residing at the cytoplasmic face of the brush border inter-microvilli tip-link.

The researchers found that both the brush border inter-microvillar tip link complex and the inner ear stereocilia tip link complex both utilize adhesive, heteromeric cadherin family proteins to build filamentous inter-microvillar/inter-stereocilia tip links that can sustain mechanical strains. Both systems use two scaffold proteins that include Harmonin as the hub to organize the respective multi-protein complex within each system.

“These results not only provide insight into the mechanistic bases of brush border microvilli formation and maintenance, but may also be valuable for understanding of some gut and/or kidney diseases caused by perturbations of brush border microvilli structures,” said Professor Zhang.

“A single mutation of genes encoding the stereocilia tip link complex can cause a disease as debilitating as Usher syndrome, while corresponding mutations in gut microvilli do not appear to cause obvious diseases in our guts. The results of our study can help scientists and clinicians to identify mutations of genes that may cause digestive diseases.”

The article can be found at: Li et al. (2016) Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex.


Source: Hong Kong University of Science and Technology.
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