AsianScientist (May 14, 2015) – A University of Tokyo research group has revealed that systemic injection of polymer micelles with a diameter of less than 50 nanometers encapsulating anticancer drugs is effective against cancer that had spread to the lymph nodes in mice. Their results have been published online in the journal ACS Nano.
The lymph nodes remove bacteria and foreign matter circulating within the body. Cancer that has spread (metastasized) to the lymph nodes is one type of malignant tumor that is extremely difficult to treat with existing therapies. So far, no efficient drug delivery system (DDS) has been found for delivering effective drugs against cancer that has metastasized to the lymph nodes.
The research group of Professor Kazunori Kataoka at the Graduate School of Engineering, University of Tokyo, compared the effect of a platinum anticancer drug encapsulated in nanocarriers of a range of sizes against cancer that had metastasized to the lymph nodes.
The group used polymeric micelles with diameters of 30 and 70 nanometers and the clinically-used 80 nanometer diameter doxorubicin-loaded liposomes (DDS Doxil®). The research group found that only the 30 nanometer nanocarriers were passed through tumor blood vessels and were able to penetrate throughout the tumor in significant quantities.
“This is the first study to show that control of particle size is an important factor in designing nanocarriers for treating cancer that has metastasized to the lymph nodes. Moreover, these results open the way to development of DDS for systemic treatment of metastasized cancers of the lymph nodes,” said Kataoka.
“These findings will be useful for development of non-surgical therapies for metastasized cancers of the lymph nodes in cases that do not present clinical symptoms.”
The article can be found at: Cabral et al. (2015) Systemic Targeting Of Lymph Node Metastasis Through The Blood Vascular System By Using Size-Controlled Nanocarriers.
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Source: The University of Tokyo.
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