Researchers Find Five Genes Associated With Glaucoma

These genes could represent new drug targets for primary angle closure glaucoma, which mainly affects ageing Asians.

AsianScientist (Apr. 21, 2016) – An international group of researchers has found five new genes strongly associated with primary angle-closure glaucoma (PACG), the most prevalent form of glaucoma in Asia. The same group reported their discovery of three genes in 2012. These eight genes provide unexpected insights into the disease process of glaucoma and how the shape of the eye could contribute to the disease even in currently healthy, asymptomatic people.

Their work, published in Nature Genetics, could pave the way for the discovery of potential new drug targets, and also build up genetic predictors that could help to screen and to direct treatment for individuals at risk of becoming blind from glaucoma.

Although preventable, glaucoma is the most common cause of irreversible blindness worldwide. PACG in particular is responsible for a high proportion of blindness in Asia, with up to 80 percent of the estimated 15 million people afflicted with PACG living in Asia.

The study, jointly led by Dr. Khor Chiea Chuen from the Genome Institute of Singapore (GIS) and Professor Aung Tin from the Singapore Eye Research Institute, involved more than 10,000 patients from 24 countries.

The researchers studied a large population size because, according to Khor, “research on complex genetic diseases such as PACG needs to be undertaken in large enough numbers so that as many people as possible are represented.”

Having treated glaucoma patients for more than 20 years, Aung observed that PACG is fairly common in elderly Singaporean Chinese, and that the disease appears to run in families—thus raising the possibility that there could also be a heritable basis for PACG.

“As Singapore faces the challenge of a rapidly ageing population, the need to research the genetics of age-related diseases, like glaucoma, also increases. Considering how prevalent PACG is in Asian populations, this discovery is significant as researchers continue to work towards precision medicine,” said GIS executive director, Professor Ng Huck Hui.

“It allows for better clinical decision-making which ultimately leads to improved healthcare outcomes for the public. This collaboration also reaffirms the importance of cross-institutional efforts; bringing our capabilities together results in high-impact research.”

The article can be found at: Khor et al. (2016) Genome-wide Association Study Identifies Five New Susceptibility Loci for Primary Angle Closure Glaucoma.


Source: Agency for Science, Technology and Research; Photo: Shutterstock.
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