The Proteins That Determine In IVF Success

A proteomics approach has shown that proteins involved in metabolism and cell adhesion can determine how receptive the womb is to IVF treatment.

AsianScientist (Mar. 25, 2015) – Women who have difficulty getting pregnant often turn to in-vitro fertilization (IVF), but it doesn’t always work. Now scientists are taking a new approach to improve the technique by studying the proteins that could help ready a uterus for an embryo to implant in its wall.

Their report, published in the Journal of Proteome Research, could help researchers develop a new treatment that could potentially increase the success rate of IVF.

Nearly 50 million couples worldwide require some kind of medical intervention to conceive. Among the most common procedures is IVF, but on average, only about one-third of all attempts lead to pregnancy.

In the majority of cases that fail, the embryo doesn’t attach to the uterine wall. Why this happens has largely remained a mystery. To address this knowledge gap, a team of researchers from the Chinese Academy of Sciences’ Key Laboratory for Receptor Research and Shanghai Jiao Tong University looked at the proteins that could play a role in this process.

The researchers tested samples of the inner uterine membrane called the endometrium from twelve women. They identified more than 2,000 proteins and found that the levels of more than 300 of them varied significantly depending on whether the endometrium was ready for embryo implantation.

Boosting or reducing the levels of some of these proteins may increase the possibility that an embryo would implant and therefore increase the IVF success rate. The researchers say the findings could also help them improve treatment of endometrium-related diseases.

The article can be found at: Chen et al. (2015) Label-Free Proteomics Uncovers Energy Metabolism and Focal Adhesion Regulations Responsive for Endometrium Receptivity.


Source: American Chemical Society; Photo: Shutterstock.
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