Vitamin A-Enriched Bananas Go On Human Trials

The orange colored pro-vitamin A-enriched banana could have a profound impact on vitamin A deficiency in East Africa.

AsianScientist (Jul 1, 2014) – The world’s first human trial of pro-vitamin A-enriched banana, expected to lift the health and well-being of millions of Ugandans and other East Africans will start very soon.

The Queensland University of Technology (QUT) project, led by Distinguished Professor James Dale and backed with close to US$10 million from the Bill and Melinda Gates Foundation, is one of the most significant biofortification projects in the world today.

“Human trial is a significant milestone for this project which started in 2005 and should see pro-vitamin A-enriched banana varieties being grown by Ugandan farmers around 2020,” Prof. Dale said.

“The Highland or East African cooking banana, which is chopped and steamed, is a staple food of many East African nations but it has low levels of micronutrients particularly pro-vitamin A and iron. The consequences of vitamin A deficiency are dire with 650,000-700,000 children world-wide dying from pro-vitamin A deficiency each year and at least another 300,000 going blind. There is very good evidence that vitamin A deficiency leads to an impaired immune system and can even have an impact on brain development.

“Good science can make a massive difference here by enriching staple crops such as Ugandan bananas with pro-vitamin A and providing poor and subsistence-farming populations with nutritionally rewarding food,” he said.

The bananas have been harvested from the QUT field trial in Innisfail, north Queensland and transported to the United States for the world-first human trial. The human trial will last for six weeks with conclusive results known by the end of the year. Previous US trials using Mongolian gerbils had proven successful.

He said while on the outside the banana plants looked just like any other banana the inside was a whole other story.

“The banana flesh of a pro-vitamin A-enriched banana is orange rather than the cream colour we are used to and in fact the greater the pro-vitamin A content the more orange the banana flesh becomes,” he said.

“We are aiming to increase the level of pro-vitamin A to a minimum level of 20 micrograms per gram dry weight in order to significantly improve the health status of African banana consumers.”

“We made all the constructs, the genes that went into bananas, and put them into bananas here at QUT. Hundreds of different permutations went into field trials up north and we tested everything to make sure our science worked here in Queensland. Now the really high-performing genes have been taken to Uganda and have been put into field trials there.”

Legislation to enable genetically modified crops to be commercialized in Uganda is currently in committee stage within the Ugandan parliament. With Ugandan Government support, legislation and regulations to enable the commercialization of genetically modified crops should be in place by 2020. Regulations enabling field trials of genetically-modified crops already exist.

He said once approved in Uganda, there would be no reason why the same technology couldn’t be used to enrich crops in surrounding East African countries including Rwanda, parts of the Democratic Republic of Congo, Kenya and Tanzania.

“This project has the potential to have a huge positive impact on staple food products across much of Africa and in so doing lift the health and wellbeing of countless millions of people over generations,” he said.

Prof. Dale said the biggest challenge facing the project was purely one of logistics, going from a small-scale project to one on a national scale but the university was working in partnerships with a team of scientists in Uganda who would, over the coming years, be joined by five Ugandan PhD students currently working in Professor Dale’s team.


Source: Queensland University of Technology; Photo: Craig ONeal/Flickr/CC.
Disclaimer: This article does not necessarily reflect the views of AsianScientist or its staff.

Asian Scientist Magazine is an award-winning science and technology magazine that highlights R&D news stories from Asia to a global audience. The magazine is published by Singapore-headquartered Wildtype Media Group.

Related Stories from Asian Scientist