Some Indigenous Groups More Vulnerable To H7N9 Viruses

Researchers have discovered that some indigenous groups will be more susceptible to the effects of the new strain of H7N9 influenza in China.

AsianScientist (Jan. 21, 2014) – Researchers at the University of Melbourne have discovered that some indigenous groups will be more susceptible to the effects of the new strain of influenza (H7N9) currently found in China.

The study, published in the journal Proceedings of the National Academy of Sciences, indicated that some indigenous people in Alaska and Australia displayed limited immunity response to the effects of influenza.

The genetic susceptibility of indigenous Australian and Alaskans would have resulted from isolation of indigenous populations from the viruses like influenza, who were not subjected to evolutionary pressures caused by the viruses over the centuries.

“The findings suggested that there may be ethnic differences in the ability to mount an immune response to the H7N9 virus,” said Associate Professor Katherine Kedzierska from the Department of Microbiology and Immunology. “Due to genetic differences in a protein complex involved in cell-mediated immune responses, people may vary in their ability to mount this kind of immune response against the H7N9 influenza virus that emerged unexpectedly in February 2013.”

The new H7N9 influenza virus, which originated in birds and caused an outbreak in China in March 2013, infected more than 140 people and resulted in a very high mortality rate of 30 percent due to severe pneumonia and acute respiratory distress syndrome.

Professor Peter Doherty, a lead author of the study from the University of Melbourne, said the study shed light on what had happened during the catastrophic 1918-1919 influenza pandemic during which high adult mortalities (up to 100 percent) were reported in some isolated Alaskan villages. 

“There are some populations that are at high risk from influenza disease,” said Doherty. “Similarly, as many as 10-20 percent of Indigenous Australians died of influenza in 1919, compared to less than one percent mortality rate in non-Indigenous Australians. Hospitalization and 
morbidity rates were also higher for Indigenous Australians. This was also the case during the recent 2009 H1N1 pandemic influenza, with 16 percent of hospitalized Australians being indigenous.”

The article can be found at: Wang Z et al. (2014) Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection.


Source: University of Melbourne.
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