amyotrophic lateral sclerosis

RNA Processing Defect Causes Motor Neuron Death

Impairment of the RNA processing pathway in motor neurons is responsible for their death in Lou Gehrig’s disease.

Model Mice Mimic ALS

Using a transgenic mouse model, scientists have found the accumulation of TPD-43 in neurons is related to motor and memory deficits.

Gene Therapy Targeting Neuromuscular Junctions Could Alleviate ALS

Using gene therapy, scientists in Japan have slowed muscle degeneration and prolonged life in a mouse model of amyotrophic lateral sclerosis.

Mitochondrial Membrane Collapse Associated With ALS

The disruption of the mitochondria-associated membrane is an indicator of amyotrophic lateral sclerosis, researchers say.

Synthetic Oil Delayed ALS Symptoms In Mice: Study

A potential treatment may help delay motor neuron loss in amyotrophic lateral sclerosis, a disease brought into the spotlight by the ice bucket challenge.

Oxford BioDynamics To Conduct ALS Biomarker Program In Malaysia

The Penang subsidiary of Oxford BioDynamics will work towards developing diagnostic tests for amyotrophic lateral sclerosis.

Tumor Suppressor Protein May Play Key Role In Amyotropic Lateral Sclerosis

A tumor suppressor protein called von Hippel Lindau may play a key role in the progression of amyotrophic lateral sclerosis.

Transgenic Pig Created For ALS Research

Unlike existing mouse models, this pig model of amyotrophic lateral sclerosis replicates the cytoplasmic accumulation of mutant proteins seen in human patients.

Alzheimer’s Proteins Used To Enhance Transfection

Self-assembling nanosheets made of amyloid-forming proteins have been used to enhance retrovirus transduction.

ACE-Inhibitors Associated With Lower ALS Risk

Drugs used to control high blood pressure might also be useful in reducing the risk of developing ALS, scientists say.