AsianScientist (Jun. 3, 2013) – Western Australian researchers hoping to demonstrate improved cardiovascular function among coffee lovers have found that drinking too much of the popular brew may actually be linked to worsening of the metabolic syndrome.
The study, published in the Journal of Agricultural and Food Chemistry by researchers from the Western Australian Institute for Medical Research (WAIMR) and the University of Western Australia’s School of Medicine and Pharmacology, looked into a compound found in coffee known as chlorogenic acid (CGA).
“Studies have shown that coffee consumption lowers the risk of developing type 2 diabetes,” said UWA’s Professor Kevin Croft. “This also included research on decaffeinated coffee, which suggested that the health benefits are from a compound in coffee apart from caffeine.
“With this in mind, we studied the effects of polyphenols, or more specifically CGAs, which are very rich in coffee but also found in tea and some fruits including plums. The CGAs were previously known for their health benefits, increasing insulin sensitivity and reducing blood pressure and body fat accumulation,” he said.
This study proved the opposite in high dosages equivalent to five or six cups of coffee per day, said WAIMR’s Assistant Professor Vance Matthews. The researchers found that the equivalent human dose of CGA fed to laboratory mice caused the abnormal retention of fat within cells. The obese mice also had a higher degree of glucose intolerance and increased insulin resistance.
“It seems that the health effects are dose-dependent. A moderate intake of coffee, up to three to four cups a day still seems to decrease the risk of developing diseases such as cardiovascular disease and type 2 diabetes,” he said.
Further, the researchers also found that CGA did not prevent weight gain in obese laboratory mice fed a high-fat diet when used at higher doses.
“People might be wasting their money if they’re buying expensive products like green coffee bean dietary supplements which are currently considered to be amazing weight loss products,” Croft said.
The article can be found at: Supplementation of a High-Fat Diet with Chlorogenic Acid Is Associated with Insulin Resistance and Hepatic Lipid Accumulation in Mice.
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Source: WAIMR.
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