Chinese Herb Suspected To Have Caused Severe Heart Disorder

A 45-year-old Chinese woman experienced severe heart arrhythmia after consuming an extract from the Aconitum plant, also known as devil’s helmet or monkshood.

AsianScientist (Nov. 24, 2015) – Chinese physicians have reported a case of potentially lethal cardiovascular symptoms induced by a traditional Chinese medicine component, aconitine, in the Canadian Journal of Cardiology.

Based on the case of a woman who presented with aconitine-induced cardiovascular symptoms, the report warns that the use of the natural ingredient may lead to severe poisoning.

A 45-year-old Chinese woman was diagnosed with a severe heart-rhythm disorder, bidirectional ventricular tachycardia (BVT), associated with aconitine poisoning. BVT is a rare form of tachycardia (characterized by a resting heart rate over 100 beats per minute) and a distinct pattern of ECG waves on presentation.

The patient’s husband reported that she had drunk about 50 milliliters of a medicinal liquid about 30 minutes before she developed a sudden drop in blood pressure and then lost consciousness. The woman had no history of previous heart-rhythm problems and there was no family history of unexpected sudden death or fatal accidents.

On examination she had a heart rate of 150 beats per minute and her blood pressure was 50/30. Her skin was cool, moist, and cyanotic. Treatment with the anti-arrhythmic agents amiodarone, metoprolol, lidocaine, and potassium chloride was ineffective. An abdominal ultrasound showed marked gastric retention. A gastric tube was used to suction out the contents of her stomach. After two hours, the patient’s BVT ceased and her circulation improved.

Investigation revealed that the patient’s blood was positive for aconitine, a substance produced by the Aconitum plant, also known as devil’s helmet or monkshood. Although well-known for its highly toxic properties, aconitine is the primary ingredient of the traditional Chinese medicine known as Fuzi, a remedy made from the processed lateral roots of Aconitum carmichaeli Debx. It is widely distributed in the southwest provinces of China and is used in small doses for its anti-inflammatory and pain-relieving effects.

“Management of potentially lethal ventricular tachyarrhythmia associated with aconitine poisoning presents a therapeutic challenge. In a previously published case, amiodarone was effective in suppressing the BVT. However, in our patient, both lidocaine and amiodarone were ineffective,” explained lead author Dr. Yi Zhong, of the Aerospace Center Hospital, Beijing.

“The public should be warned of the risk of severe poisoning that can accompany traditional Chinese medicinal usage of Fuzi,” Yi concluded.

Reacting to the report, Dr. P. Timothy Pollak of the Department of Medicine at the University of Calgary, also highlighted the need to be cautious about natural remedies.

“Not all products of Mother Nature are free of harm. This case report reminds us that aconitine is not the only naturally derived substance that can cause potentially lethal ventricular tachyarrhythmias, including BVT. The report also demonstrates the human tendency to think that if a little is good, more must be better,” said Pollak.

Pollak advises clinicians to be aware of what their patients are taking and be prepared to discuss alternative remedies, at least at a basic level.

“Dodging the discussion can only lend credibility to any patient suspicions that as a practitioner of Western medicine, you have been denied the secrets of alternative remedies or are hiding them for ulterior motives. This report serves as a timely illustration that alternative remedies do have implications for the practice of cardiology that cannot be ignored.”

The article can be found at: Zhao et al. (2015) An Unusual Etiology for Bidirectional Ventricular Tachycardia.

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Source: Elsevier; Photo: Leonora Enking/Flickr/CC.
Disclaimer: This article does not necessarily reflect the views of AsianScientist or its staff.

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