Why Some Skinny People Still Get Fatty Liver

Researchers have identified a mutation in a gene, carried by 20 percent of all Japanese, associated with non-alcoholic fatty liver disease in normal weight patients.

AsianScientist (Aug. 5, 2015) – A gene mutation has been found to contribute to non-alcoholic fatty liver disease (NAFLD), a form of liver disease closely linked to obesity, in normal weight subjects. These results have been published in PLOS ONE.

Researchers at Kumamoto University and the Japanese Red Cross Kumamoto Hospital found that carriers of the PNPLA3 mutant genotype were at a greater risk for NAFLD and other health problems compared to non-carriers even when the carrier was not obese.

Two types of studies were performed on subjects from a health screening program of the Red Cross Kumamoto Hospital: a cross-sectional study of 740 subjects and a retrospective longitudinal study of 393 subjects who had five years of available medical records. Those with habitual alcohol intake and/or with positive hepatitis B and C tests were excluded from analysis regarding the risk for NAFLD. The associations between the genotype and the risk of NAFLD or a decline in renal function were analyzed among overweight (BMI ≥ 25 kg/m2) or normal weight (BMI < 25 kg/m2) subjects.

Dr. Kentaro Oniki’s group provided preliminary findings that even normal-weight carriers of the mutant genotype (about 20 percent of all Japanese people) are at a higher risk for NAFLD and renal function dysfunction when compared to those without the gene. This suggests that the mutation may be used for early classification of individuals at high-risk for NAFLD and decreased renal function no matter their weight.

“We hope that clarifying the risk factors for NAFLD among normal-weight subjects will help to identify susceptible populations for the early prevention and treatment of NAFLD and its complications,” said Oniki. “Especially in Asians.”

The article can be found at: Oniki et al. (2015) Influence of the PNPLA3 rs738409 Polymorphism on Non-Alcoholic Fatty Liver Disease and Renal Function among Normal Weight Subjects.

———

Source: Kumamoto University; Photo: Shutterstock.
Disclaimer: This article does not necessarily reflect the views of AsianScientist or its staff.

Asian Scientist Magazine is an award-winning science and technology magazine that highlights R&D news stories from Asia to a global audience. The magazine is published by Singapore-headquartered Wildtype Media Group.

Related Stories from Asian Scientist