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Nanoparticle Delivers, Tracks Cancer Drugs

Researchers have synthesized a new nanoparticle that delivers cancer drugs to cells while monitoring the drug release in real time.

| November 7, 2013 | In the Lab

Asian Scientist (Nov. 7, 2013) - Researchers in Australia have synthesized a new iron oxide nanoparticle that delivers cancer drugs to cells while simultaneously monitoring the drug release in real time.

The result, published in ACS Nano, represents an important development for the emerging field of theranostics – a term that refers to nanoparticles that can treat and diagnose disease.

“Iron oxide nanoparticles that can track drug delivery will provide the possibility to adapt treatments for individual patients,” says Associate Professor Cyrille Boyer, a senior author of the study.

By understanding how the cancer drug is released and its effect on the cells and surrounding tissue, doctors can adjust doses to achieve the best result.

Importantly, the multidisciplinary team demonstrated for the first time the use of a technique called fluorescence lifetime imaging to monitor the drug release inside lung cancer cells.

“Usually, the drug release is determined using model experiments on the lab bench, but not in the cells,” says Boyer. “This is significant as it allows us to determine the kinetic movement of drug release in a true biological environment.”

Magnetic iron oxide nanoparticles have been studied widely because of their applications as contrast agents in magnetic resonance imaging, or MRI. Several recent studies have explored the possibility of equipping these contrast agents with drugs.

However, there are limited studies describing how to load chemotherapy drugs onto the surface of magnetic iron oxide nanoparticles, and no studies that have effectively proven that these drugs can be delivered inside the cell.

With this latest study, the researchers engineered a new way of loading the drugs onto the nanoparticle’s polymer surface, and demonstrated for the first time that the particles are delivering their drug inside the cells.

“This is very important because it shows that bench chemistry is working inside the cells,” says Boyer. “The next step in the research is to move to in-vivo applications.”

The article can be found at: Basuki JS et al. (2013) Using Fluorescence Lifetime Imaging Microscopy To Monitor Theranostic Nanoparticle Uptake And Intracellular Doxorubicin Release.


Source: University of New South Wales; Photo: snre/Flickr/CC.
Disclaimer: This article does not necessarily reflect the views of AsianScientist or its staff.

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