Clinical Trial Uses South Pacific Plant Kava To Treat Anxiety
An Australian clinical study has shown that Kava, a medicinal South Pacific plant, significantly reduced the symptoms of people suffering from anxiety.
AsianScientist (May 13, 2013) - An Australian clinical study has shown that Kava, a medicinal South Pacific plant, could be an alternative treatment for the hundreds of thousands of Australians who suffer from Generalized Anxiety Disorders (GAD).
GAD is a complex condition that significantly affects people's day-to-day lives, said lead researcher, Dr. Jerome Sarris from Department of Psychiatry at the University of Melbourne.
"Based on previous work we have recognized that plant based medicines may be a viable treatment for patients with chronic anxiety. In this study we've been able to show that Kava offers a potential natural alternative for the treatment of chronic clinical anxiety. Unlike some other options it has less risk of dependency and less potential for side effects," he said.
The study, led by the University of Melbourne and published in the Journal of Clinical Psychopharmacology, found that people's genetic differences (polymorphisms) of certain neurobiological proteins called GABA transporters, may modify their response to Kava (Piper methysticum).
"If this finding is replicated, it may pave the way for simple genetic tests to determine which people may be likely to have a beneficial anxiety-reducing effect from taking Kava," Sarris said.
During the eight-week study, 75 patients with clinically diagnosed Generalized Anxiety Disorder were given Kava or placebo, and anxiety levels were regularly assessed. Participants in the Kava group were given tablets twice per day consisting of water-soluble extracted Kava (peeled rootstock) for a total dose of 120 mg of kavalactones for the first three-week controlled phase. In cases of non-response this was increased to a double-dose twice per day for the second three-week controlled phase. Participants in the placebo group took matching dummy tablets in the same manner.
Results showed a significant reduction in anxiety for the Kava group compared to the placebo group at the end of the study. In participants diagnosed with moderate to severe GAD, Kava had an even greater effect in reducing anxiety. Following the completion of the controlled phase, 26 percent of the Kava group were classified as in remission from their symptoms compared to six percent of the placebo group.
According to the study, Kava was also well tolerated. Results showed no significant differences across the two groups for liver function which had previously been a concern for Kava's medicinal use. In addition there were no considerable adverse reactions that could be attributed to Kava and no difference in withdrawal or addiction between the groups.
An additional novel finding of the study, recently published in Phytotherapy Research, was that Kava increased women's sex drive compared to those in the placebo group, believed to be due to the reduction of anxiety, rather than any aphrodisiac effect.
Future studies confirming the genetic relationship to therapeutic response, and any libido-improving effects from Kava is now required, said Sarris.
Source: University of Melbourne.
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